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KMID : 0383820140760050218
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Tuberculosis and Respiratory Diseases
2014 Volume.76 No. 5 p.218 ~ p.225
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Progression-Free Survival: An Important Prognostic Marker for Long-Term Survival of Small Cell Lung Cancer
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Park Myoung-Rin
Park Yeon-Hee
Choi Jae-Woo
Park Dong-Il
Chung Chae-Uk
Moon Jae-Young
Park Hee-Sun
Jung Sung-Soo
Kim Ju-Ock
Kim Sun-Young
Lee Jeong-Eun
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Abstract
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Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients’ survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals.
Materials and Methods: A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox’s analyses were performed to identify the independent factors.
Results: The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25?6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59?6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98?41.73; p<0.001) were independent prognostic markers for poor survival rates.
Conclusion: In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.
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KEYWORD
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Small Cell Lung Carcinoma, Prognosis, Disease-Free Survival
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